Partial healing effects of St. John’s wort oil on the rat excisional wound model

Objective: St. John’s wort (SJW) oil (Hypericum perforatum) has been used for its immunomodulatory and anti-inflammatory effects. Several studies have shown the efficacy of SJW on wound healing. The aim this study is to assess effectiveness using a combination biochemical, histopathological laser Doppler evaluations. Materials Methods: Sixteen young Wistar albino rats were as case control groups (having 8 in each group). After anesthesia protocol, 6 mm punch biopsy was taken from six separate sites rats’ dorsal skin. Three wounds stitched (closed wounds); three left they (open wounds). administered topically group once day 14 days. Controls did not receive any treatment. Results: There no statistical difference blood perfusion between groups. No present GPx (glutathione peroxidase)values. Rat MDA (malonyldialdehyde) values higher compared group. found be beneficial effective within some histological parameters. Conclusion: may an salve Nevertheless, judgment uncertain due low sample size. We encourage further promising natural medicine.